diff --git a/netbox/dcim/api/views.py b/netbox/dcim/api/views.py
index f045f1bb4..80a991736 100644
--- a/netbox/dcim/api/views.py
+++ b/netbox/dcim/api/views.py
@@ -20,7 +20,7 @@ from netbox.api.authentication import IsAuthenticatedOrLoginNotRequired
 from netbox.api.metadata import ContentTypeMetadata
 from netbox.api.pagination import StripCountAnnotationsPaginator
 from netbox.api.renderers import TextRenderer
-from netbox.api.viewsets import NetBoxModelViewSet
+from netbox.api.viewsets import NetBoxModelViewSet, MPTTLockedMixin
 from netbox.api.viewsets.mixins import SequentialBulkCreatesMixin
 from netbox.constants import NESTED_SERIALIZER_PREFIX
 from utilities.api import get_serializer_for_model
@@ -98,7 +98,7 @@ class PassThroughPortMixin(object):
 # Regions
 #
 
-class RegionViewSet(NetBoxModelViewSet):
+class RegionViewSet(MPTTLockedMixin, NetBoxModelViewSet):
     queryset = Region.objects.add_related_count(
         Region.objects.all(),
         Site,
@@ -114,7 +114,7 @@ class RegionViewSet(NetBoxModelViewSet):
 # Site groups
 #
 
-class SiteGroupViewSet(NetBoxModelViewSet):
+class SiteGroupViewSet(MPTTLockedMixin, NetBoxModelViewSet):
     queryset = SiteGroup.objects.add_related_count(
         SiteGroup.objects.all(),
         Site,
@@ -149,7 +149,7 @@ class SiteViewSet(NetBoxModelViewSet):
 # Locations
 #
 
-class LocationViewSet(NetBoxModelViewSet):
+class LocationViewSet(MPTTLockedMixin, NetBoxModelViewSet):
     queryset = Location.objects.add_related_count(
         Location.objects.add_related_count(
             Location.objects.all(),
@@ -350,7 +350,7 @@ class DeviceBayTemplateViewSet(NetBoxModelViewSet):
     filterset_class = filtersets.DeviceBayTemplateFilterSet
 
 
-class InventoryItemTemplateViewSet(NetBoxModelViewSet):
+class InventoryItemTemplateViewSet(MPTTLockedMixin, NetBoxModelViewSet):
     queryset = InventoryItemTemplate.objects.prefetch_related('device_type__manufacturer', 'role')
     serializer_class = serializers.InventoryItemTemplateSerializer
     filterset_class = filtersets.InventoryItemTemplateFilterSet
@@ -538,7 +538,7 @@ class DeviceBayViewSet(NetBoxModelViewSet):
     brief_prefetch_fields = ['device']
 
 
-class InventoryItemViewSet(NetBoxModelViewSet):
+class InventoryItemViewSet(MPTTLockedMixin, NetBoxModelViewSet):
     queryset = InventoryItem.objects.prefetch_related('device', 'manufacturer', 'tags')
     serializer_class = serializers.InventoryItemSerializer
     filterset_class = filtersets.InventoryItemFilterSet
diff --git a/netbox/netbox/api/viewsets/__init__.py b/netbox/netbox/api/viewsets/__init__.py
index 5fe81b1f5..c6794bb61 100644
--- a/netbox/netbox/api/viewsets/__init__.py
+++ b/netbox/netbox/api/viewsets/__init__.py
@@ -3,6 +3,8 @@ import logging
 from django.core.exceptions import ObjectDoesNotExist, PermissionDenied
 from django.db import transaction
 from django.db.models import ProtectedError
+from django_pglocks import advisory_lock
+from netbox.constants import ADVISORY_LOCK_KEYS
 from rest_framework import mixins as drf_mixins
 from rest_framework.response import Response
 from rest_framework.viewsets import GenericViewSet
@@ -157,3 +159,22 @@ class NetBoxModelViewSet(
         logger.info(f"Deleting {model._meta.verbose_name} {instance} (PK: {instance.pk})")
 
         return super().perform_destroy(instance)
+
+
+class MPTTLockedMixin:
+    """
+    Puts pglock on objects that derive from MPTTModel for parallel API calling.
+    Note: If adding this to a view, must add the model name to ADVISORY_LOCK_KEYS
+    """
+
+    def create(self, request, *args, **kwargs):
+        with advisory_lock(ADVISORY_LOCK_KEYS[self.queryset.model._meta.model_name]):
+            return super().create(request, *args, **kwargs)
+
+    def update(self, request, *args, **kwargs):
+        with advisory_lock(ADVISORY_LOCK_KEYS[self.queryset.model._meta.model_name]):
+            return super().update(request, *args, **kwargs)
+
+    def destroy(self, request, *args, **kwargs):
+        with advisory_lock(ADVISORY_LOCK_KEYS[self.queryset.model._meta.model_name]):
+            return super().destroy(request, *args, **kwargs)
diff --git a/netbox/netbox/constants.py b/netbox/netbox/constants.py
index d69edc69c..2f4ee8e6b 100644
--- a/netbox/netbox/constants.py
+++ b/netbox/netbox/constants.py
@@ -11,8 +11,19 @@ RQ_QUEUE_LOW = 'low'
 # When adding a new key, pick something arbitrary and unique so that it is easily searchable in
 # query logs.
 ADVISORY_LOCK_KEYS = {
+    # Available object locks
     'available-prefixes': 100100,
     'available-ips': 100200,
     'available-vlans': 100300,
     'available-asns': 100400,
+
+    # MPTT locks
+    'region': 105100,
+    'sitegroup': 105200,
+    'location': 105300,
+    'tenantgroup': 105400,
+    'contactgroup': 105500,
+    'wirelesslangroup': 105600,
+    'inventoryitem': 105700,
+    'inventoryitemtemplate': 105800,
 }
diff --git a/netbox/tenancy/api/views.py b/netbox/tenancy/api/views.py
index 39c86d80e..71a4961c3 100644
--- a/netbox/tenancy/api/views.py
+++ b/netbox/tenancy/api/views.py
@@ -3,7 +3,7 @@ from rest_framework.routers import APIRootView
 from circuits.models import Circuit
 from dcim.models import Device, Rack, Site
 from ipam.models import IPAddress, Prefix, VLAN, VRF
-from netbox.api.viewsets import NetBoxModelViewSet
+from netbox.api.viewsets import NetBoxModelViewSet, MPTTLockedMixin
 from tenancy import filtersets
 from tenancy.models import *
 from utilities.utils import count_related
@@ -23,7 +23,7 @@ class TenancyRootView(APIRootView):
 # Tenants
 #
 
-class TenantGroupViewSet(NetBoxModelViewSet):
+class TenantGroupViewSet(MPTTLockedMixin, NetBoxModelViewSet):
     queryset = TenantGroup.objects.add_related_count(
         TenantGroup.objects.all(),
         Tenant,
@@ -58,7 +58,7 @@ class TenantViewSet(NetBoxModelViewSet):
 # Contacts
 #
 
-class ContactGroupViewSet(NetBoxModelViewSet):
+class ContactGroupViewSet(MPTTLockedMixin, NetBoxModelViewSet):
     queryset = ContactGroup.objects.add_related_count(
         ContactGroup.objects.all(),
         Contact,
diff --git a/netbox/wireless/api/views.py b/netbox/wireless/api/views.py
index 1103cec37..a6cc9f535 100644
--- a/netbox/wireless/api/views.py
+++ b/netbox/wireless/api/views.py
@@ -1,6 +1,6 @@
 from rest_framework.routers import APIRootView
 
-from netbox.api.viewsets import NetBoxModelViewSet
+from netbox.api.viewsets import NetBoxModelViewSet, MPTTLockedMixin
 from wireless import filtersets
 from wireless.models import *
 from . import serializers
@@ -14,7 +14,7 @@ class WirelessRootView(APIRootView):
         return 'Wireless'
 
 
-class WirelessLANGroupViewSet(NetBoxModelViewSet):
+class WirelessLANGroupViewSet(MPTTLockedMixin, NetBoxModelViewSet):
     queryset = WirelessLANGroup.objects.add_related_count(
         WirelessLANGroup.objects.all(),
         WirelessLAN,
diff --git a/netbox/wireless/models.py b/netbox/wireless/models.py
index 046918535..e8e48eef8 100644
--- a/netbox/wireless/models.py
+++ b/netbox/wireless/models.py
@@ -2,7 +2,6 @@ from django.core.exceptions import ValidationError
 from django.db import models
 from django.urls import reverse
 from django.utils.translation import gettext_lazy as _
-from mptt.models import MPTTModel
 
 from dcim.choices import LinkStatusChoices
 from dcim.constants import WIRELESS_IFACE_TYPES